Programme

Moderation: Wolfgang A. Linke, Münster, Germany

11:30 OC-14-01
Mechanistic insights into microvascular dysfunction in INOCA using human resistance arteries
Jessica Meades, Thomas Jepps, Ylva Hellsten; Copenhagen, Denmark

11:45 OC-14-02
Use of heart-forming organoids derived from human iPS cells carrying a mutation in the MYBPC3 gene to study the role of cMyBP-C in human heart development
Fiona Soehngen, Karina Ivaskevica, Birgit Piep, Felix Osten, Annika Franke, Lika Drakhlis, Robert Zweigerdt, Theresia Kraft, Sarah Konze; Hannover

12:00 OC-14-03
Heterozygous Titin Deletion Alters Right Ventricular Stiffness and Remodelling in a Mouse Model of Pulmonary Hypertension
Kimberley Stein, Annika J. Klotz, Marion Müller, Anna Klinke, Wolfgang A. Linke, Daniela Wenzel; Bochum, Germany, Münster, Germany, Freiburg, Germany, Köln, Germany

12:15 OC-14-04
DEL-1deficiency exacerbates inflammatory cardiac remodeling in Angiotensin II–induced hypertension
Alina Maslakova, Maria Knyrim, Michael Marterstock, Anupam Das, Stephan Speier, Peter Mirtschink, Triantafyllos Chavakis, Andreas Deußen, Arka Baksi, Irakli Kopaliani; Dresden, Germany

12:30 OC-14-05
Selective titin cleavage disrupts cardiac mechanical homeostasis to drive diastolic dysfunction and fibroblast activation
Johanna Freundt, Paulina Hartmann, Andreas Unger, Christine Löscher, Franziska Koser, Annika J. Klotz, Lydia Wachsmuth, Michaela Door, Susanne Hille, Richard Holtmeier, Jonathan Kirk, Cornelius Faber, Verena Hoerr, Oliver J. Müller, Wolfgang A. Linke; Münster, Germany, Chicago, United States, Kiel, Germany

12:45 OC-14-06
Combined PKC- and AKT/ERK-linked receptor activation induces endocytic T-tubule loss in adult rat cardiomyocytes
Alexandra Kuhn, Tilmann Volk, Thomas Seidel; Erlangen, Germany, Weimar, Germany