Programme

Chairs: Thomas Eschenhagen, Hamburg, Germany; Karoline Morhenn, Hamburg, Germany

15:40 TS-04-01
Current challenges in heart failure management
Christina Magnussen, Hamburg, Germany

16:10 TS-04-02
Regenerative therapies for heart failure at the transition to clinical trials
Florian Weinberger, Hamburg, Germany

16:40 TS-04-03
Restoring the elasticity of heart muscle
Michael Gotthardt, Berlin, Germany

Short description:
Heart failure remains a major global health burden, with high morbidity and mortality despite substantial therapeutic advances. The disease reflects a complex interplay between molecular mechanisms, clinical heterogeneity, and translational challenges, and while recent progress has reshaped diagnosis and treatment, major gaps remain in understanding patient-specific pathophysiology and implementing innovative therapies. This symposium integrates clinical, translational, and mechanistic perspectives on heart failure, addressing current challenges in patient management, emerging regenerative strategies approaching clinical application, and new insights into disease mechanisms in heart failure with preserved ejection fraction, including the therapeutic potential of targeting myocardial stiffness. Together, the contributions provide an overview of key translational developments that are shaping the future of heart failure therapy.