Programme

Chairs: Claudia Stäubert, Leipzig, Germany; Marjan Slak Rupnik, Vienna, Austria

09:00 GS-05-01
Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity
Doreen Thor, Leipzig, Germany

09:20 GS-05-02
Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes
Haaglim Cho, Bad Nauheim, Germany

09:40 GS-05-03
SUCNR1: linking succinate sensing to hormone secretion
Sonia Fernandez-Veledo, Tarragona, Spain

10:00 GS-05-04
Effects of Arginine Vasopressin on Islet Cells in Pancreatic Tissue Slices
Nastja Murko, Maribor, Slovenia

Short description:
Physiological regulation emerges from the cell’s ability to communicate effectively within complex tissue environments. G protein-coupled receptors (GPCRs) integrate diverse cellular inputs into context-specific physiological responses. This symposium will highlight recent studies demonstrating how GPCR-mediated signal integration governs key physiological processes. A central aspect to be covered is how selected GPCRs, such as those of the adhesion GPCR family and metabolite-sensing GPCRs, regulate food intake, insulin secretion, energy and glucose homeostasis, or endothelial function. Together, these studies reveal GPCRs as integrative modules that convert cellular signals into defined physiological outputs. By bridging molecular mechanisms with in vivo function, the symposium underscores how GPCRs coordinate intercellular communication to maintain systemic homeostasis and how their dysregulation contributes to disease.