Programme

Chairs: Stine Helene Falsig Pedersen, Copenhagen, Denmark; Jeppe Praetorius, Arhus, Denmark

11:30 GS-10-01
Novel Insights into the Functional Inhibition of the Human Na+/H+ Exchanger SLC9B2
David Drew, Stockholm, Sweden

12:00 GS-10-02
Integrative structural analysis of the human endosomal Na⁺/H⁺ exchanger NHE6
Henriette Elisabeth Autzen, Copenhagen, Denmark

12:30 GS-10-03
The endosomal Na⁺/H⁺ exchanger NHE6: roles of the transporter in brain metabolism
Lara Sach, Copenhagen, Denmark

12:45 GS-10-04
Mechanistic Insights into the Na+-dependent HCO3- Transport by NBCn2 (SLC4A10)
Lasse Messell Desdorf, Arhus Denmark

Short description:
In-depth knowledge of the relationship between three-dimensional structure and function of membrane proteins has recently become evident by the emergence of a set of analytical tools such as single particle electron microscopy and molecular dynamics simulations. This insight is not only of interest for the narrow field of protein structure biology but creates new hypotheses regarding their function and paves the way for endeavours into studies of plasma membrane and organellar transport physiology. The field also has a strong pathophysiological relevance and even presents a promise for development of physiologically relevant agonists and antagonists. These developments are strongly represented in the Nordic region and should serve as a huge inspiration broadly among classical physiologists.