Programme

15:40 GS-08-01
Intricacies of the glomerular endothelium
Simon Satchell, Bristol, United Kingdom

16:02 GS-08-02
GBM: Just how dynamic are you?
Rachel Lennon, Manchester, United Kingdom

16:24 GS-08-03
The slit diaphragm, an unusual cell-cell junction: New structure-function insights
Achilleas Frangakis, Franfurt a. M., Germany

16:46 GS-08-04
The podocyte and filtration barrier permeability: New concepts
Linus Butt, Cologne, Germany

Short description:
The glomerular filtration barrier is a dynamic, multi-layered structure whose dysfunction underlies proteinuria and progressive kidney disease. This symposium will address recent mechanistic insights into the regulation of glomerular permeability, focusing on endothelial specialization, dynamic remodeling of the glomerular basement membrane, and the slit diaphragm as an unconventional cell–cell junction. Novel structural concepts of the blood–urine barrier and emerging models of podocyte-driven control of filtration will be discussed. Together, these contributions aim to refine our understanding of glomerular barrier function and identify new conceptual frameworks relevant to glomerular disease pathogenesis and therapy.